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Sucrose, or table sugar, is made of glucose and fructose, in equal proportions. It is naturally occurring and easy to digest, but of course high in calories.
Glucose is what cells use for energy. Starchy foods (including staples like rice or potatoes or wheat) provide a lot of it for the body. Brain cells in particular use a lot of it. Corn syrup is mostly glucose. Its metabolism requires insulin, so diabetics must be careful with any sugar with lots of glucose. The body converts extra glucose to glycogen, as energy storage against later need, and either uses it for energy or converts it to fat if a need doesn’t arise.
Fructose is found in fruits and honey, though not so much in corn. It doesn’t require insulin for its metabolism, so it is very useful in making sweets for diabetics. However, cells can’t use it directly, so it is either turned into glucose for immediate metabolism, or turned into glycogen for storage and later use or conversion to fat.
Getting these sugars from their natural sources (potatoes or rice or apples or raspberries) isn’t the sort of diet likely to cause problems. It is when they are concentrated and eaten in large quantities that a problem arises (namely, blood sugar and metabolic problems, and obesity).
Corn Syrup is starchy. It contains a lot of glucose, but it isn’t a super-sweet sugar, so it is used to thicken food products, and it is useful in baking to keep cookies moist and so on.
High Fructose Corn Syrup is modified Corn Syrup, where much of the glucose has been converted to fructose, which is much, much sweeter. The resulting ratio of glucose to fructose varies with the product but it generally ranges from 40 to 90 percent fructose. Since fructose isn’t usable directly for cell metabolism, it mostly gets converted to glycogen and then to fat.
The big problem with HFCS (as it is popularly abbreviated) is that it is very, very cheap due to corn subsidies, and since it is also stable and soft, it makes products that taste good and have a long shelf life. This means that manufacturers use it everywhere, and in some surprising products, such as bread. Overconsumption of anything is a problem, and HFCS is so ubiquitous that it is hard to avoid overconsumption.
The warnings (which I do heed - this is a biased answer) are largely due to the rise in obesity and insulin problems that have shown high correlation with increased consumption of HFCS in the United States. Our family tries hard to avoid bringing products with it in the house, not because small amounts would hurt us, but because it is a good habit, and it keeps me aware of sugars while I shop and cook.
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