I just answered this a few days ago, on
this question, and my views haven't changed.
Quoting myself:
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Here is the low-down on diet pills.
The prescription ones all work. They work differently and you might have to try a couple to see which works for you. But you WILL lose weight.
The problem is, unless you permanently change your eating and exercise habits to stay at the level they were during the pill-taking, you'll gain the weight back. (Been there, done that, over and over.) And you can't take any of the pills forever. They are all short-term.
The only FDA approved over the counter (OTC) diet pill is Alli. I am sure that if you follow the diet plan stringently it works great because you have to cut out all fat, and fat is where lots of calories lurk. And then Alli (like its prescription cousin Orlistat) removes even more of the fat from what you ate. However the side effects are horrific. Basically all the fat the pill "removes" from your food leaks from your butt all day. I have never taken it but friends of mine have and they say that it works great but it's so disgusting to have this yellow-orange oil leaking constantly that they stopped taking it.
All the other OTC diet pills are junk. They say right on the label that they are not intended to treat any disease or condition. If they work, it's because you follow the diet plan enclosed, or via the placebo effect. You can read my rant against non-FDA approved supplements in
this answer.
I honestly don't know what to tell you. I am very fat and I have dieted, exercised, taken non-prescription diet pills, taken prescription diet pills, lived on foul-tasting diet shakes..and I am still fat. I can starve myself and work out 2 hours a day and lose a couple of pounds, but if I slack off, they come right back.
I wish something worked permanently. Even gastric bypass isn't a fool-proof solution--I know several people who got it years ago and are gaining weight again.
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One of your topics was "fat blockers". The only FDA approved fat blocker is Orlistat/Alli. If you can stick to their low-fat regime and the side effects of the pills don't bother you, you can increase your weight loss by 50% over just following the low-fat diet. Alli is sold over the counter; you can get it anywhere, even Walmart.